Effective Use of Dilated Convolutions for Segmenting Small Object Instances in Remote Sensing Imagery

Thanks to recent advances in CNNs, solid improvements have been made in semantic segmentation of high resolution remote sensing imagery. However, most of the previous works have not fully taken into account the specific difficulties that exist in remote sensing tasks. One of such difficulties is that objects are small and crowded in remote sensing imagery. To tackle with this challenging task we have proposed a novel architecture called local feature extraction (LFE) module attached on top of dilated front-end module. The LFE module is based on our findings that aggressively increasing dilation factors fails to aggregate local features due to sparsity of the kernel, and detrimental to small objects. The proposed LFE module solves this problem by aggregating local features with decreasing dilation factor. We tested our network on three remote sensing datasets and acquired remarkably good results for all datasets especially for small objects

The Autonomous System Architecture of the Small SAR Satellite Operation System and On-Orbit Autonomous Operation Experiences

We are developing a small SAR (Synthetic Aperture Radar) satellite for our commercial solution business. Our goal is to deploy at least 30 small SAR satellites in orbit and enable frequent and persistent observations until the Mid 2020s. We launched the satellite on 15th December 2020 by Rocket Lab\u27s Electron. We waited for a month until we took the first image to confirm the complete evacuation of the residual air and contaminations to prevent any hazardous electrical discharge. We took the first image on 8th February. The satellite is now operating in a fine state and acquiring images requested by the customers. We will make six satellite constellation until 2023. We also describe our system architecture including our solution business and the satellite development. Our business development team and the satellite development team are communicating with each other for adequate system architecture and agile satellite development. Our business development team acquires many novel needs from our customers. One of our goals is an agile reflection of the user\u27s needs for the satellite development. We are now establishing a process and an organization to extract those business needs, analyze them and identify the key requirements for the satellite performances and functions. We believe that one important challenge is to achieve application layer integration from a customer business system to a satellite on-board software through solution platform, data platform, satellite control ground system, and the satellite itself. We try to harmonize the software and information processes of the application layer, although the platform where the application is located, the organization where staffs belong, and their culture are different. We wish our activities contribute to our small satellite community or ecosystem and a system architecture including component suppliers, communication service providers, and data processing service providers

Pharmacologic characterization of TBP1901, a prodrug form of aglycone curcumin, and CRISPR-Cas9 screen for therapeutic targets of aglycone curcumin

プロドラッグ型クルクミン注射製剤の抗腫瘍効果及び治療標的の包括的な解析 --安全性の高い抗がん薬としての開発に期待--. 京都大学プレスリリース. 2022-10-21.Curcumin (aglycone curcumin) has antitumor properties in a variety of malignancies via the alteration of multiple cancer-related biological pathways; however, its clinical application has been hampered due to its poor bioavailability. To overcome this limitation, we have developed a synthesized curcumin β-D-glucuronide sodium salt (TBP1901), a prodrug form of aglycone curcumin. In this study, we aimed to clarify the pharmacologic characteristics of TBP1901. In β-glucuronidase (GUSB)-proficient mice, both curcumin β-D-glucuronide and its active metabolite, aglycone curcumin, were detected in the blood after TBP1901 injection, whereas only curcumin β-D-glucuronide was detected in GUSB-impaired mice, suggesting that GUSB plays a pivotal role in the conversion of TBP1901 into aglycone curcumin in vivo. TBP1901 itself had minimal antitumor effects in vitro, whereas it demonstrated significant antitumor effects in vivo. Genome-wide clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 screen disclosed the genes associated with NF-κB signaling pathway and mitochondria were among the highest hit. In vitro, aglycone curcumin inhibited NF-kappa B signaling pathways whereas it caused production of reactive oxygen species (ROS). ROS scavenger, N-acetyl-L-cysteine, partially reversed antitumor effects of aglycone curcumin. In summary, TBP1901 can exert antitumor effects as a prodrug of aglycone curcumin through GUSB-dependent activation

Management of gingival hyperplasia associated with sore mucositis in an acute leukemia patient

Gingival enlargement is a prominent symptom in patients with myelomonocytic leukemia (AML-M4) and acute monocytic leukemia (AML-M5). Poor oral hygiene may aggravate the condition. However, patients are apt to avoid oral care out of fear of the pain and hemorrhage associated with the myelopoietic disorder. Here we report a case of a patient with AML-M4 in whom oral care intervention from an early stage improved the quality of life by relieving the pain associated with mucositis and gingival overgrowth aggravated by preceding periodontal lesions

Genome Features of “Dark-Fly”, a Drosophila Line Reared Long-Term in a Dark Environment

Organisms are remarkably adapted to diverse environments by specialized metabolisms, morphology, or behaviors. To address the molecular mechanisms underlying environmental adaptation, we have utilized a Drosophila melanogaster line, termed “Dark-fly”, which has been maintained in constant dark conditions for 57 years (1400 generations). We found that Dark-fly exhibited higher fecundity in dark than in light conditions, indicating that Dark-fly possesses some traits advantageous in darkness. Using next-generation sequencing technology, we determined the whole genome sequence of Dark-fly and identified approximately 220,000 single nucleotide polymorphisms (SNPs) and 4,700 insertions or deletions (InDels) in the Dark-fly genome compared to the genome of the Oregon-R-S strain, a control strain. 1.8% of SNPs were classified as non-synonymous SNPs (nsSNPs: i.e., they alter the amino acid sequence of gene products). Among them, we detected 28 nonsense mutations (i.e., they produce a stop codon in the protein sequence) in the Dark-fly genome. These included genes encoding an olfactory receptor and a light receptor. We also searched runs of homozygosity (ROH) regions as putative regions selected during the population history, and found 21 ROH regions in the Dark-fly genome. We identified 241 genes carrying nsSNPs or InDels in the ROH regions. These include a cluster of alpha-esterase genes that are involved in detoxification processes. Furthermore, analysis of structural variants in the Dark-fly genome showed the deletion of a gene related to fatty acid metabolism. Our results revealed unique features of the Dark-fly genome and provided a list of potential candidate genes involved in environmental adaptation

Meissner state of high-Tc oxide thin films observed by scanning superconducting quantum interference device microscopy

The magnetic level of the Meissner state in high-Tc oxide thin films is investigated using scanning superconducting quantum interference device microscopy. We find that the Meissner level observed is not uniquely determined and shifts with the temperature and depends on the doping level of individual oxide films. The result at higher temperature may be interpreted by a grain-coupled model which reflects the granular nature of high-Tc oxides and is useful for evaluation of high-Tc film quality